Polynucleotide injections: what the current evidence actually shows and the questions to ask before trying a trending treatment

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Polynucleotide injections are injectable treatments derived from purified DNA fragments that work by stimulating tissue repair and supporting the skin's natural regenerative processes. Clinical evidence suggests improvements in skin quality, hydration, and elasticity, though research is still maturing. Suitability depends on individual skin assessment rather than trend alone.
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Regenerative Aesthetics Explained: Which Collagen-Stimulating Treatments Are Evidence-Based and Which Are Still Unproven

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Regenerative aesthetics refers to treatments that stimulate the skin's own collagen and elastin production rather than simply filling or relaxing tissue. Evidence-based options include polynucleotides, hyaluronic acid skin boosters, calcium hydroxylapatite biostimulators, and medical-grade microneedling. Several newer modalities, including certain exosome therapies and growth factor serums, currently lack sufficient clinical data to support routine use.
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Melasma, Sun Damage or Post-Inflammatory Marks? Why Identifying Your Pigmentation Type Matters

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Melasma, sun-induced pigmentation, and post-inflammatory hyperpigmentation are three distinct conditions that share a similar appearance but have different causes, patterns, and treatment responses. Identifying your specific pigmentation type before starting any treatment is essential, because an approach that improves one type can actively worsen another.
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Tracking Pigmentation Over a Treatment Protocol: What Progress Actually Looks Like

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Pigmentation treatment progress is rarely linear. Genuine improvement in melasma typically becomes measurable after eight to twelve weeks, with meaningful change often visible only at the three to six month mark. Clinical tools such as VISIA imaging capture subsurface changes that the naked eye misses, making structured check-ins essential for accurate progress assessment.
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