Regenerative aesthetics refers to treatments that stimulate the skin's own collagen and elastin production rather than simply filling or relaxing tissue. Evidence-based options include polynucleotides, hyaluronic acid skin boosters, calcium hydroxylapatite biostimulators, and medical-grade microneedling. Several newer modalities, including certain exosome therapies and growth factor serums, currently lack sufficient clinical data to support routine use.